A mild and efficient reaction for conversion of carboxylic acids into acid bromides with ethyl tribromoacetate/triphenylphosphine under acid-free conditions

Dong Ho Kang; Tae Young Joo; Eun Hwa Lee; Skaydaw Chaysripongkul; Warinthorn Chavasiri; Doo Ok Jang

doi:10.1016/j.tetlet.2006.06.013

A mild and efficient reaction for conversion of carboxylic acids into acid bromides with ethyl tribromoacetate/triphenylphosphine under acid-free conditions

Dong Ho Kang, Tae Young Joo, Eun Hwa Lee, Skaydaw Chaysripongkul, Warinthorn Chavasiri, Doo Ok Jang

Chemistry and Medical Chemistry

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Acid bromides were prepared efficiently from carboxylic acids with readily available ethyl tribromoacetate and triphenylphosphine at room temperature under neutral conditions. The present process is applicable to the preparation of various acid bromides from aromatic and aliphatic carboxylic acids. Aromatic carboxylic acids were found to be more reactive than aliphatic carboxylic acids under reaction conditions.

Original language	English
Pages (from-to)	5693-5696
Number of pages	4
Journal	Tetrahedron Letters
Volume	47
Issue number	32
DOIs	https://doi.org/10.1016/j.tetlet.2006.06.013
Publication status	Published - 2006 Aug 7

Bibliographical note

Funding Information:
This work was supported by Joint Research Project under the KOSEF-NRCT cooperative program (F01-2004-000-10252-0) and CBMH.

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2006.06.013

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title = "A mild and efficient reaction for conversion of carboxylic acids into acid bromides with ethyl tribromoacetate/triphenylphosphine under acid-free conditions",

abstract = "Acid bromides were prepared efficiently from carboxylic acids with readily available ethyl tribromoacetate and triphenylphosphine at room temperature under neutral conditions. The present process is applicable to the preparation of various acid bromides from aromatic and aliphatic carboxylic acids. Aromatic carboxylic acids were found to be more reactive than aliphatic carboxylic acids under reaction conditions.",

author = "Kang, {Dong Ho} and Joo, {Tae Young} and Lee, {Eun Hwa} and Skaydaw Chaysripongkul and Warinthorn Chavasiri and Jang, {Doo Ok}",

note = "Funding Information: This work was supported by Joint Research Project under the KOSEF-NRCT cooperative program (F01-2004-000-10252-0) and CBMH.",

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T1 - A mild and efficient reaction for conversion of carboxylic acids into acid bromides with ethyl tribromoacetate/triphenylphosphine under acid-free conditions

AU - Kang, Dong Ho

AU - Joo, Tae Young

AU - Lee, Eun Hwa

AU - Chaysripongkul, Skaydaw

AU - Chavasiri, Warinthorn

AU - Jang, Doo Ok

N1 - Funding Information: This work was supported by Joint Research Project under the KOSEF-NRCT cooperative program (F01-2004-000-10252-0) and CBMH.

PY - 2006/8/7

Y1 - 2006/8/7

N2 - Acid bromides were prepared efficiently from carboxylic acids with readily available ethyl tribromoacetate and triphenylphosphine at room temperature under neutral conditions. The present process is applicable to the preparation of various acid bromides from aromatic and aliphatic carboxylic acids. Aromatic carboxylic acids were found to be more reactive than aliphatic carboxylic acids under reaction conditions.

AB - Acid bromides were prepared efficiently from carboxylic acids with readily available ethyl tribromoacetate and triphenylphosphine at room temperature under neutral conditions. The present process is applicable to the preparation of various acid bromides from aromatic and aliphatic carboxylic acids. Aromatic carboxylic acids were found to be more reactive than aliphatic carboxylic acids under reaction conditions.

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U2 - 10.1016/j.tetlet.2006.06.013

DO - 10.1016/j.tetlet.2006.06.013

M3 - Article

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SN - 0040-4039

VL - 47

SP - 5693

EP - 5696

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 32

ER -

A mild and efficient reaction for conversion of carboxylic acids into acid bromides with ethyl tribromoacetate/triphenylphosphine under acid-free conditions

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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