A learning-based method for solving ill-posed nonlinear inverse problems: A simulation study of lung EIT

This paper proposes a new approach for solving ill-posed nonlinear inverse problems. For ease of explanation of the proposed approach, we use the example of lung electrical impedance tomography (EIT), which is known to be a nonlinear and ill-posed inverse problem. Conventionally, penaltybased regularization methods have been used to deal with the ill-posed problem. However, experiences over the last three decades have shown methodological limitations in utilizing prior knowledge about tracking expected imaging features for medical diagnosis. The proposed method’s paradigm is completely different from conventional approaches; the proposed reconstruction uses a variety of training data sets to generate a low dimensional manifold of approximate solutions, which allows conversion of the ill-posed problem to a well-posed one. Variational autoencoder was used to produce a compact and dense representation for lung EIT images with a low dimensional latent space. Then, we learn a robust connection between the EIT data and the low dimensional latent data. Numerical simulations validate the effectiveness and feasibility of the proposed approach.