A histological evaluation of novel cyanoacrylate-based β-TCP composite in rat calvarial defects

Sang Bae Lee, Kyeong Jun Park, Douq Youn Lee, Jeong Jong Park, Jae Sun Hwang, Yong Keun Lee, Kyoung Nam Kim, Kwang Mahn Kim

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6 Citations (Scopus)


In this study, the osteoconductive properties of novel cyanoacrylate-based filling materials for bone defect were evaluated. A new filling material was prepared by mixing Histoacryl® and acid-treated β-tricalcium phosphate (β-TCP). Mixing weight ratio of acid-treated β-TCP to Histoacryl® was 5:1. 12 male Spraque-Dawley rats were used in this study. The animals were divided into 4 groups. Critical-sized calvarial defects (8 mm) were created in 9 animals, and then the defects were treated with dense pellet specimen, porous cement-like specimen, and untreated defect for surgical control group. Augmentation treatments were carried out in 3 animals. Histological analysis revealed excellent ostgeoconductive properties of new filling materials. But, some of β-TCP particle in the cement-like group were encapsulated by fibrous connective tissue. For the dense pellet group and augmentation treatment group, shape and stability were better maintained during the implantation time than cement like group. These results indicate that our novel β-TCP/Histoacryl® composite have the potential to serve as filling materials for bone defects in the dental and plastic surgery.

Original languageEnglish
Pages (from-to)1133-1136
Number of pages4
JournalKey Engineering Materials
Volume309-311 II
Publication statusPublished - 2006

All Science Journal Classification (ASJC) codes

  • General Materials Science
  • Mechanics of Materials
  • Mechanical Engineering


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