A fully addressable micro-array chip integrated with cascade multiplexors for selective cell loading and retrieval

Xia Lou; Jaehoon Chung; Young Ji Kim; Il Joo Cho; Euisik Yoon

doi:10.1109/SENSOR.2009.5285869

A fully addressable micro-array chip integrated with cascade multiplexors for selective cell loading and retrieval

Xia Lou, Jaehoon Chung, Young Ji Kim, Il Joo Cho, Euisik Yoon

Yonsei Advanced Science Institute

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We report a fully addressable micro-array chip integrated with cascade multiplexors for selective cell loading and retrieval in a stacked PDMS (polydimethylsiloxane) layers for microfluidic control. This chip provides the addressable manipulation of large number of cells at single cell resolution. A cascade multiplexer is developed to reduce the number of pneumatic control inputs integrated on chip. Hydrodynamic structures are incorporated for efficient single cell loading as well as retrieval. We have fabricated the prototype device in an 8x8 array and demonstrated the feasibility of single cell manipulation. We have loaded and cultured C2C12 cells in the prototype chip and then successfully retrieved the viable cells.

Original language	English
Title of host publication	TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
Pages	1301-1304
Number of pages	4
DOIs	https://doi.org/10.1109/SENSOR.2009.5285869
Publication status	Published - 2009
Event	TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems - Denver, CO, United States Duration: 2009 Jun 21 → 2009 Jun 25

Publication series

Name	TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems

Other

Other	TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
Country/Territory	United States
City	Denver, CO
Period	09/6/21 → 09/6/25

All Science Journal Classification (ASJC) codes

Hardware and Architecture
Electrical and Electronic Engineering

Access to Document

10.1109/SENSOR.2009.5285869

Cite this

Lou, X., Chung, J., Kim, Y. J., Cho, I. J., & Yoon, E. (2009). A fully addressable micro-array chip integrated with cascade multiplexors for selective cell loading and retrieval. In TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems (pp. 1301-1304). [5285869] (TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems). https://doi.org/10.1109/SENSOR.2009.5285869

Lou, Xia ; Chung, Jaehoon ; Kim, Young Ji et al. / A fully addressable micro-array chip integrated with cascade multiplexors for selective cell loading and retrieval. TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems. 2009. pp. 1301-1304 (TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems).

@inproceedings{fc7f68e2a47d4874982e80294407f2f3,

title = "A fully addressable micro-array chip integrated with cascade multiplexors for selective cell loading and retrieval",

abstract = "We report a fully addressable micro-array chip integrated with cascade multiplexors for selective cell loading and retrieval in a stacked PDMS (polydimethylsiloxane) layers for microfluidic control. This chip provides the addressable manipulation of large number of cells at single cell resolution. A cascade multiplexer is developed to reduce the number of pneumatic control inputs integrated on chip. Hydrodynamic structures are incorporated for efficient single cell loading as well as retrieval. We have fabricated the prototype device in an 8x8 array and demonstrated the feasibility of single cell manipulation. We have loaded and cultured C2C12 cells in the prototype chip and then successfully retrieved the viable cells.",

author = "Xia Lou and Jaehoon Chung and Kim, {Young Ji} and Cho, {Il Joo} and Euisik Yoon",

year = "2009",

doi = "10.1109/SENSOR.2009.5285869",

language = "English",

isbn = "9781424441938",

series = "TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems",

pages = "1301--1304",

booktitle = "TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems",

note = "TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems ; Conference date: 21-06-2009 Through 25-06-2009",

}

Lou, X, Chung, J, Kim, YJ, Cho, IJ & Yoon, E 2009, A fully addressable micro-array chip integrated with cascade multiplexors for selective cell loading and retrieval. in TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems., 5285869, TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems, pp. 1301-1304, TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems, Denver, CO, United States, 09/6/21. https://doi.org/10.1109/SENSOR.2009.5285869

A fully addressable micro-array chip integrated with cascade multiplexors for selective cell loading and retrieval. / Lou, Xia; Chung, Jaehoon; Kim, Young Ji et al.
TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems. 2009. p. 1301-1304 5285869 (TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - A fully addressable micro-array chip integrated with cascade multiplexors for selective cell loading and retrieval

AU - Lou, Xia

AU - Chung, Jaehoon

AU - Kim, Young Ji

AU - Cho, Il Joo

AU - Yoon, Euisik

PY - 2009

Y1 - 2009

N2 - We report a fully addressable micro-array chip integrated with cascade multiplexors for selective cell loading and retrieval in a stacked PDMS (polydimethylsiloxane) layers for microfluidic control. This chip provides the addressable manipulation of large number of cells at single cell resolution. A cascade multiplexer is developed to reduce the number of pneumatic control inputs integrated on chip. Hydrodynamic structures are incorporated for efficient single cell loading as well as retrieval. We have fabricated the prototype device in an 8x8 array and demonstrated the feasibility of single cell manipulation. We have loaded and cultured C2C12 cells in the prototype chip and then successfully retrieved the viable cells.

AB - We report a fully addressable micro-array chip integrated with cascade multiplexors for selective cell loading and retrieval in a stacked PDMS (polydimethylsiloxane) layers for microfluidic control. This chip provides the addressable manipulation of large number of cells at single cell resolution. A cascade multiplexer is developed to reduce the number of pneumatic control inputs integrated on chip. Hydrodynamic structures are incorporated for efficient single cell loading as well as retrieval. We have fabricated the prototype device in an 8x8 array and demonstrated the feasibility of single cell manipulation. We have loaded and cultured C2C12 cells in the prototype chip and then successfully retrieved the viable cells.

UR - http://www.scopus.com/inward/record.url?scp=71449107034&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=71449107034&partnerID=8YFLogxK

U2 - 10.1109/SENSOR.2009.5285869

DO - 10.1109/SENSOR.2009.5285869

M3 - Conference contribution

AN - SCOPUS:71449107034

SN - 9781424441938

T3 - TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems

SP - 1301

EP - 1304

BT - TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems

T2 - TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems

Y2 - 21 June 2009 through 25 June 2009

ER -

Lou X, Chung J, Kim YJ, Cho IJ, Yoon E. A fully addressable micro-array chip integrated with cascade multiplexors for selective cell loading and retrieval. In TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems. 2009. p. 1301-1304. 5285869. (TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems). doi: 10.1109/SENSOR.2009.5285869

A fully addressable micro-array chip integrated with cascade multiplexors for selective cell loading and retrieval

Abstract

Publication series

Other

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this