A fluorogenic probe targeting two spatially separated enzymes for selective imaging of cancer cells

Sang Hyun Park, Hyoje Jung, Yujun Kim, Injae Shin

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

We describe a fluorogenic probe BocLys(Ac)-AB-FC targeting both histone deacetylases (HDACs) and cathepsin l, which are overexpressed in spatially separated subcellular organelles of cancer cells. The results show that this fluorogenic probe can be used for selective cancer cell imaging without interference arising from normal cells.

Original languageEnglish
Pages (from-to)4079-4082
Number of pages4
JournalChemical Communications
Volume58
Issue number25
DOIs
Publication statusPublished - 2022 Mar 3

Bibliographical note

Publisher Copyright:
© 2022 The Royal Society of Chemistry

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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