A flexible fish-bone-shaped neural probe strengthened by biodegradable silk coating for enhanced biocompatibility

Fan Wu; Maesoon Im; Euisik Yoon

doi:10.1109/TRANSDUCERS.2011.5969356

A flexible fish-bone-shaped neural probe strengthened by biodegradable silk coating for enhanced biocompatibility

Fan Wu, Maesoon Im, Euisik Yoon

Yonsei Advanced Science Institute

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

56 Citations (Scopus)

Abstract

This paper reports a fish-bone-shaped polyimide neural probe for chronic recording applications. This unique design aims to minimize tissue reaction by having flexible substrate, small dimensions, large separation distance between electrodes and the probe shank, as well as large substrate openings. A biodegradable silk polymer is coated around the polyimide structure to provide temporary mechanical strength during insertion. The time required for the complete degradation of silk can be controlled within the range of 30 minutes to 25 hours by water annealing process. In-vitro insertion of the fabricated silk-coated probe into brain tissue has been successfully demonstrated.

Original language	English
Title of host publication	2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11
Pages	966-969
Number of pages	4
DOIs	https://doi.org/10.1109/TRANSDUCERS.2011.5969356
Publication status	Published - 2011
Event	2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 - Beijing, China Duration: 2011 Jun 5 → 2011 Jun 9

Publication series

Name	2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11

Other

Other	2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11
Country/Territory	China
City	Beijing
Period	11/6/5 → 11/6/9

All Science Journal Classification (ASJC) codes

Hardware and Architecture
Electrical and Electronic Engineering

Access to Document

10.1109/TRANSDUCERS.2011.5969356

Cite this

Wu, F., Im, M., & Yoon, E. (2011). A flexible fish-bone-shaped neural probe strengthened by biodegradable silk coating for enhanced biocompatibility. In 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 (pp. 966-969). Article 5969356 (2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11). https://doi.org/10.1109/TRANSDUCERS.2011.5969356

Wu, Fan ; Im, Maesoon ; Yoon, Euisik. / A flexible fish-bone-shaped neural probe strengthened by biodegradable silk coating for enhanced biocompatibility. 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11. 2011. pp. 966-969 (2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11).

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title = "A flexible fish-bone-shaped neural probe strengthened by biodegradable silk coating for enhanced biocompatibility",

abstract = "This paper reports a fish-bone-shaped polyimide neural probe for chronic recording applications. This unique design aims to minimize tissue reaction by having flexible substrate, small dimensions, large separation distance between electrodes and the probe shank, as well as large substrate openings. A biodegradable silk polymer is coated around the polyimide structure to provide temporary mechanical strength during insertion. The time required for the complete degradation of silk can be controlled within the range of 30 minutes to 25 hours by water annealing process. In-vitro insertion of the fabricated silk-coated probe into brain tissue has been successfully demonstrated.",

author = "Fan Wu and Maesoon Im and Euisik Yoon",

year = "2011",

doi = "10.1109/TRANSDUCERS.2011.5969356",

language = "English",

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series = "2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11",

pages = "966--969",

booktitle = "2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11",

note = "2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 ; Conference date: 05-06-2011 Through 09-06-2011",

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Wu, F, Im, M & Yoon, E 2011, A flexible fish-bone-shaped neural probe strengthened by biodegradable silk coating for enhanced biocompatibility. in 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11., 5969356, 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11, pp. 966-969, 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11, Beijing, China, 11/6/5. https://doi.org/10.1109/TRANSDUCERS.2011.5969356

A flexible fish-bone-shaped neural probe strengthened by biodegradable silk coating for enhanced biocompatibility. / Wu, Fan; Im, Maesoon; Yoon, Euisik.
2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11. 2011. p. 966-969 5969356 (2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AB - This paper reports a fish-bone-shaped polyimide neural probe for chronic recording applications. This unique design aims to minimize tissue reaction by having flexible substrate, small dimensions, large separation distance between electrodes and the probe shank, as well as large substrate openings. A biodegradable silk polymer is coated around the polyimide structure to provide temporary mechanical strength during insertion. The time required for the complete degradation of silk can be controlled within the range of 30 minutes to 25 hours by water annealing process. In-vitro insertion of the fabricated silk-coated probe into brain tissue has been successfully demonstrated.

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Wu F, Im M, Yoon E. A flexible fish-bone-shaped neural probe strengthened by biodegradable silk coating for enhanced biocompatibility. In 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11. 2011. p. 966-969. 5969356. (2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11). doi: 10.1109/TRANSDUCERS.2011.5969356

A flexible fish-bone-shaped neural probe strengthened by biodegradable silk coating for enhanced biocompatibility

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