A der(1;15)(q10;q10) is a rare nonrandom whole-arm translocation in patients with acute lymphoblastic leukemia

Tae Sung Park; Jaewoo Song; Kyung A. Lee; Sang Guk Lee; Seoyoung Yoon; Jin Seok Kim; Chuhl Joo Lyu; Jong Rak Choi

doi:10.1016/j.cancergencyto.2007.08.008

A der(1;15)(q10;q10) is a rare nonrandom whole-arm translocation in patients with acute lymphoblastic leukemia

Tae Sung Park, Jaewoo Song, Kyung A. Lee, Sang Guk Lee, Seoyoung Yoon, Jin Seok Kim, Chuhl Joo Lyu, Jong Rak Choi

Research output: Contribution to journal › Article › peer-review

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Abstract

A rare karyotypic event, der(1;15)(q10;q10), which involves the whole long arms of chromosomes 1 and 15, has been reported in patients with various conditions, including acute myelogenous leukemia, myelodysplastic syndrome, polycythemia vera, and multiple myeloma. Only 27 cases of unbalanced der(1;15)(q10;q10) have been documented in the literature as single or complexed chromosomal abnormalities in hematological malignancies. Here, we describe two cases of acute lymphoblastic leukemia with der(1;15)(q10;q10), and review the previous reports. Although more case studies are needed, we suggest that der(1;15)(q10;q10) should be considered a nonrandom chromosomal abnormality in hematological malignancies including both lymphoid and myeloid neoplasms.

Original language	English
Pages (from-to)	132-135
Number of pages	4
Journal	Cancer genetics and cytogenetics
Volume	179
Issue number	2
DOIs	https://doi.org/10.1016/j.cancergencyto.2007.08.008
Publication status	Published - 2007 Dec

All Science Journal Classification (ASJC) codes

Molecular Biology
Genetics
Cancer Research

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10.1016/j.cancergencyto.2007.08.008

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title = "A der(1;15)(q10;q10) is a rare nonrandom whole-arm translocation in patients with acute lymphoblastic leukemia",

abstract = "A rare karyotypic event, der(1;15)(q10;q10), which involves the whole long arms of chromosomes 1 and 15, has been reported in patients with various conditions, including acute myelogenous leukemia, myelodysplastic syndrome, polycythemia vera, and multiple myeloma. Only 27 cases of unbalanced der(1;15)(q10;q10) have been documented in the literature as single or complexed chromosomal abnormalities in hematological malignancies. Here, we describe two cases of acute lymphoblastic leukemia with der(1;15)(q10;q10), and review the previous reports. Although more case studies are needed, we suggest that der(1;15)(q10;q10) should be considered a nonrandom chromosomal abnormality in hematological malignancies including both lymphoid and myeloid neoplasms.",

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AU - Lee, Sang Guk

AU - Yoon, Seoyoung

AU - Kim, Jin Seok

AU - Lyu, Chuhl Joo

AU - Choi, Jong Rak

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A der(1;15)(q10;q10) is a rare nonrandom whole-arm translocation in patients with acute lymphoblastic leukemia

Abstract

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