A convenient, one-pot procedure for the preparation of acyl and sulfonyl fluorides using Cl3CCN, Ph3P, and TBAF(t -BuOH) 4

Joong Gon Kim; Doo Ok Jang

doi:10.1055/s-0030-1259051

A convenient, one-pot procedure for the preparation of acyl and sulfonyl fluorides using Cl₃CCN, Ph₃P, and TBAF(t -BuOH) ₄

Joong Gon Kim, Doo Ok Jang

Chemistry and Medical Chemistry

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Various carboxylic acids were converted into acyl fluorides in excellent yields by treatment with trichloroacetonitrile, triphenylphosphine, and TBAF(t-BuOH)₄ at room temperature. The reaction was applicable to the preparation of acid-sensitive amino acid fluorides without deprotection or rearrangement

Original language	English
Article number	U08710ST
Pages (from-to)	3049-3052
Number of pages	4
Journal	Synlett
Issue number	20
DOIs	https://doi.org/10.1055/s-0030-1259051
Publication status	Published - 2010

All Science Journal Classification (ASJC) codes

Organic Chemistry

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10.1055/s-0030-1259051

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title = "A convenient, one-pot procedure for the preparation of acyl and sulfonyl fluorides using Cl3CCN, Ph3P, and TBAF(t -BuOH) 4",

abstract = "Various carboxylic acids were converted into acyl fluorides in excellent yields by treatment with trichloroacetonitrile, triphenylphosphine, and TBAF(t-BuOH)4 at room temperature. The reaction was applicable to the preparation of acid-sensitive amino acid fluorides without deprotection or rearrangement",

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PY - 2010

Y1 - 2010

N2 - Various carboxylic acids were converted into acyl fluorides in excellent yields by treatment with trichloroacetonitrile, triphenylphosphine, and TBAF(t-BuOH)4 at room temperature. The reaction was applicable to the preparation of acid-sensitive amino acid fluorides without deprotection or rearrangement

AB - Various carboxylic acids were converted into acyl fluorides in excellent yields by treatment with trichloroacetonitrile, triphenylphosphine, and TBAF(t-BuOH)4 at room temperature. The reaction was applicable to the preparation of acid-sensitive amino acid fluorides without deprotection or rearrangement

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A convenient, one-pot procedure for the preparation of acyl and sulfonyl fluorides using Cl₃CCN, Ph₃P, and TBAF(t -BuOH) ₄

Abstract

All Science Journal Classification (ASJC) codes

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