A categorical review on electroanalytical determination of non-narcotic over-the-counter abused antitussive drugs

Neeta Thapliyal; Harun Patel; Rajshekhar Karpoormath; Rajendra N. Goyal; Rajkumar Patel

doi:10.1016/j.talanta.2015.04.061

A categorical review on electroanalytical determination of non-narcotic over-the-counter abused antitussive drugs

Neeta Thapliyal, Harun Patel, Rajshekhar Karpoormath, Rajendra N. Goyal, Rajkumar Patel

Integrated Sciences and Engineering Division

Research output: Contribution to journal › Review article › peer-review

8 Citations (Scopus)

Abstract

Dextromethorphan (DXM) and diphenhydramine (DPH) are two commonly used over-the-counter non-narcotic antitussive drugs. Recent reports reveal the widespread abuse of DXM and DPH due to their euphoric and alcohol-like effects. Due to their medicinal importance as well as the apparent increase in their use as abused drugs, it has become critical to determine them in samples of biological, clinical and pharmaceutical interest. The electrochemical techniques for drug analysis have gathered considerable attention due to their pronounced selectivity, sensitivity and simplicity. The given review presents a compilation of published voltammetric and potentiometric methods developed for determination of DXM and DPH. It critically highlights the analytical performances, revealing the recent trends and progress in the specified approach for their analysis. The review forms a basis for further progress in this field and development of improved electrochemical sensors to determine the drug.

Original language	English
Pages (from-to)	157-163
Number of pages	7
Journal	Talanta
Volume	142
DOIs	https://doi.org/10.1016/j.talanta.2015.04.061
Publication status	Published - 2015 Sept 1

Bibliographical note

Funding Information:
The authors are thankful to College of Health Sciences, University of KwaZulu-Natal, South Africa (Grant no. CS 78), Westville Campus, Durban, South Africa for providing financial support.

Publisher Copyright:
© 2015 Elsevier B.V. All rights reserved.

Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.

All Science Journal Classification (ASJC) codes

Analytical Chemistry

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10.1016/j.talanta.2015.04.061

Cite this

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title = "A categorical review on electroanalytical determination of non-narcotic over-the-counter abused antitussive drugs",

abstract = "Dextromethorphan (DXM) and diphenhydramine (DPH) are two commonly used over-the-counter non-narcotic antitussive drugs. Recent reports reveal the widespread abuse of DXM and DPH due to their euphoric and alcohol-like effects. Due to their medicinal importance as well as the apparent increase in their use as abused drugs, it has become critical to determine them in samples of biological, clinical and pharmaceutical interest. The electrochemical techniques for drug analysis have gathered considerable attention due to their pronounced selectivity, sensitivity and simplicity. The given review presents a compilation of published voltammetric and potentiometric methods developed for determination of DXM and DPH. It critically highlights the analytical performances, revealing the recent trends and progress in the specified approach for their analysis. The review forms a basis for further progress in this field and development of improved electrochemical sensors to determine the drug.",

author = "Neeta Thapliyal and Harun Patel and Rajshekhar Karpoormath and Goyal, {Rajendra N.} and Rajkumar Patel",

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AU - Karpoormath, Rajshekhar

AU - Goyal, Rajendra N.

AU - Patel, Rajkumar

N1 - Funding Information: The authors are thankful to College of Health Sciences, University of KwaZulu-Natal, South Africa (Grant no. CS 78), Westville Campus, Durban, South Africa for providing financial support. Publisher Copyright: © 2015 Elsevier B.V. All rights reserved. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Dextromethorphan (DXM) and diphenhydramine (DPH) are two commonly used over-the-counter non-narcotic antitussive drugs. Recent reports reveal the widespread abuse of DXM and DPH due to their euphoric and alcohol-like effects. Due to their medicinal importance as well as the apparent increase in their use as abused drugs, it has become critical to determine them in samples of biological, clinical and pharmaceutical interest. The electrochemical techniques for drug analysis have gathered considerable attention due to their pronounced selectivity, sensitivity and simplicity. The given review presents a compilation of published voltammetric and potentiometric methods developed for determination of DXM and DPH. It critically highlights the analytical performances, revealing the recent trends and progress in the specified approach for their analysis. The review forms a basis for further progress in this field and development of improved electrochemical sensors to determine the drug.

AB - Dextromethorphan (DXM) and diphenhydramine (DPH) are two commonly used over-the-counter non-narcotic antitussive drugs. Recent reports reveal the widespread abuse of DXM and DPH due to their euphoric and alcohol-like effects. Due to their medicinal importance as well as the apparent increase in their use as abused drugs, it has become critical to determine them in samples of biological, clinical and pharmaceutical interest. The electrochemical techniques for drug analysis have gathered considerable attention due to their pronounced selectivity, sensitivity and simplicity. The given review presents a compilation of published voltammetric and potentiometric methods developed for determination of DXM and DPH. It critically highlights the analytical performances, revealing the recent trends and progress in the specified approach for their analysis. The review forms a basis for further progress in this field and development of improved electrochemical sensors to determine the drug.

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A categorical review on electroanalytical determination of non-narcotic over-the-counter abused antitussive drugs

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

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