A case of nephrotic syndrome in a patient with Churg-Strauss syndrome

Sun Young Park, Jae Hyun Chang, Hyun Wook Kim, Dong Ki Kim, Eun Young Kim, Jung Tak Park, Tae Ik Chang, Jung Won Park, Hyeon Joo Jeong, Dae Suk Han, Shin Wook Kang

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5 Citations (Scopus)


Renal involvement in Churg-Strauss syndrome (CSS) is not uncommon, but nephrotic syndrome is rarely reported in patients with CSS. A 25-year-old woman with a long history of bronchial asthma presented to our hospital with a chief complaint of generalized edema. Laboratory studies revealed normocytic normochromic anemia, marked eosinophilia, positive anti-neutrophil cytoplasmic antibody, hypoalbuminemia, and hypercholesterolemia. Urinalysis showed heavy proteinuria (4+) without significant casts. The 24-hour urinary protein excretion was 6.5 g with a selective index of 0.35. Echocardiography and X-ray of the paranasal sinuses suggested restrictive cardiomyopathy and maxillary sinusitis, respectively. Diagnoses of CSS and nephrotic syndrome were made on the basis of clinical and laboratory findings. Renal biopsy was performed, and pathologic findings revealed focal segmental glomerulosclerosis with mesangiolysis. The patient's clinical symptoms and proteinuria improved markedly after combined treatment with corticosteroids and cyclophosphamide. Herein, we report a case of nephrotic syndrome in a patient with CSS.

Original languageEnglish
Pages (from-to)1385-1388
Number of pages4
JournalRheumatology International
Issue number10
Publication statusPublished - 2010 Aug

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology


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