A case of ALK-rearranged adenocarcinoma with small cell carcinoma-like transformation and resistance to crizotinib

Yoon Jin Cha; Byoung Chul Cho; Hye Ryun Kim; Hye Jeong Lee; Hyo Sup Shim

doi:10.1016/j.jtho.2015.12.097

A case of ALK-rearranged adenocarcinoma with small cell carcinoma-like transformation and resistance to crizotinib

Yoon Jin Cha, Byoung Chul Cho, Hye Ryun Kim, Hye Jeong Lee, Hyo Sup Shim

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

65 Citations (Scopus)

Abstract

Histologic changes can be involved in resistance to anticancer drugs. Transformation to small cell lung carcinoma (SCLC) following treatment with EGFR tyrosine kinase inhibitors has been reported in patients with EGFR-mutant lung adenocarcinoma. Herein, we report a case of ALK-rearranged lung adenocarcinoma with SCLC-like histology in a metastatic abdominal nodule that was resistant to crizotinib therapy.

Original language	English
Pages (from-to)	e55-e58
Journal	Journal of Thoracic Oncology
Volume	11
Issue number	5
DOIs	https://doi.org/10.1016/j.jtho.2015.12.097
Publication status	Published - 2016

Bibliographical note

Publisher Copyright:
© 2016 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

All Science Journal Classification (ASJC) codes

Oncology
Pulmonary and Respiratory Medicine

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10.1016/j.jtho.2015.12.097

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abstract = "Histologic changes can be involved in resistance to anticancer drugs. Transformation to small cell lung carcinoma (SCLC) following treatment with EGFR tyrosine kinase inhibitors has been reported in patients with EGFR-mutant lung adenocarcinoma. Herein, we report a case of ALK-rearranged lung adenocarcinoma with SCLC-like histology in a metastatic abdominal nodule that was resistant to crizotinib therapy.",

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AU - Shim, Hyo Sup

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AB - Histologic changes can be involved in resistance to anticancer drugs. Transformation to small cell lung carcinoma (SCLC) following treatment with EGFR tyrosine kinase inhibitors has been reported in patients with EGFR-mutant lung adenocarcinoma. Herein, we report a case of ALK-rearranged lung adenocarcinoma with SCLC-like histology in a metastatic abdominal nodule that was resistant to crizotinib therapy.

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A case of ALK-rearranged adenocarcinoma with small cell carcinoma-like transformation and resistance to crizotinib

Abstract

Bibliographical note

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