A capacitive biosensor based on an interdigitated electrode with nanoislands

Ha Wook Jung; Young Wook Chang; Ga yeon Lee; Sungbo Cho; Min Jung Kang; Jae Chul Pyun

doi:10.1016/j.aca.2014.07.006

A capacitive biosensor based on an interdigitated electrode with nanoislands

Ha Wook Jung, Young Wook Chang, Ga yeon Lee, Sungbo Cho, Min Jung Kang, Jae Chul Pyun

Department of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

A capacitive biosensor based on an interdigitated electrode (IDE) with nanoislands was developed for label-free detection of antigen-antibody interactions. To enable sensitive capacitive detection of protein adsorption, the nanoislands were fabricated between finger electrodes of the IDE. The effect of the nanoislands on the sensitive capacitive measurement was estimated using horseradish peroxidase (HRP) as a model protein. Additionally, a parylene-A film was coated on the IDE with nanoislands to improve the efficiency of protein immobilization. By using HRP and hepatitis B virus surface antigen (HBsAg) as model analytes, the effect of the parylene-A film on the capacitive detection of protein adsorption was demonstrated.

Original language	English
Pages (from-to)	27-34
Number of pages	8
Journal	Analytica Chimica Acta
Volume	844
DOIs	https://doi.org/10.1016/j.aca.2014.07.006
Publication status	Published - 2014 Sept 24

Bibliographical note

Funding Information:
This research was supported by the National Research Foundation of Korea ( 2013-056267 , 2013-056331 , 2013-054339 and 2013R1A1A2065723 ).

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Biochemistry
Environmental Chemistry
Spectroscopy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.aca.2014.07.006

Cite this

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title = "A capacitive biosensor based on an interdigitated electrode with nanoislands",

abstract = "A capacitive biosensor based on an interdigitated electrode (IDE) with nanoislands was developed for label-free detection of antigen-antibody interactions. To enable sensitive capacitive detection of protein adsorption, the nanoislands were fabricated between finger electrodes of the IDE. The effect of the nanoislands on the sensitive capacitive measurement was estimated using horseradish peroxidase (HRP) as a model protein. Additionally, a parylene-A film was coated on the IDE with nanoislands to improve the efficiency of protein immobilization. By using HRP and hepatitis B virus surface antigen (HBsAg) as model analytes, the effect of the parylene-A film on the capacitive detection of protein adsorption was demonstrated.",

author = "Jung, {Ha Wook} and Chang, {Young Wook} and Lee, {Ga yeon} and Sungbo Cho and Kang, {Min Jung} and Pyun, {Jae Chul}",

note = "Funding Information: This research was supported by the National Research Foundation of Korea ( 2013-056267 , 2013-056331 , 2013-054339 and 2013R1A1A2065723 ). ",

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doi = "10.1016/j.aca.2014.07.006",

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AU - Jung, Ha Wook

AU - Chang, Young Wook

AU - Lee, Ga yeon

AU - Cho, Sungbo

AU - Kang, Min Jung

AU - Pyun, Jae Chul

N1 - Funding Information: This research was supported by the National Research Foundation of Korea ( 2013-056267 , 2013-056331 , 2013-054339 and 2013R1A1A2065723 ).

PY - 2014/9/24

Y1 - 2014/9/24

N2 - A capacitive biosensor based on an interdigitated electrode (IDE) with nanoislands was developed for label-free detection of antigen-antibody interactions. To enable sensitive capacitive detection of protein adsorption, the nanoislands were fabricated between finger electrodes of the IDE. The effect of the nanoislands on the sensitive capacitive measurement was estimated using horseradish peroxidase (HRP) as a model protein. Additionally, a parylene-A film was coated on the IDE with nanoislands to improve the efficiency of protein immobilization. By using HRP and hepatitis B virus surface antigen (HBsAg) as model analytes, the effect of the parylene-A film on the capacitive detection of protein adsorption was demonstrated.

AB - A capacitive biosensor based on an interdigitated electrode (IDE) with nanoislands was developed for label-free detection of antigen-antibody interactions. To enable sensitive capacitive detection of protein adsorption, the nanoislands were fabricated between finger electrodes of the IDE. The effect of the nanoislands on the sensitive capacitive measurement was estimated using horseradish peroxidase (HRP) as a model protein. Additionally, a parylene-A film was coated on the IDE with nanoislands to improve the efficiency of protein immobilization. By using HRP and hepatitis B virus surface antigen (HBsAg) as model analytes, the effect of the parylene-A film on the capacitive detection of protein adsorption was demonstrated.

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A capacitive biosensor based on an interdigitated electrode with nanoislands

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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