A biodegradable polymersome containing Bcl-xL siRNA and doxorubicin as a dual delivery vehicle for a synergistic anticancer effect

Hyun Ouk Kim; Eunjung Kim; Yonghee An; Jihye Choi; Eunji H.O. Jang; Eun Bi Choi; Aastha Kukreja; Myeong Hoon Kim; Byunghoon Kang; Dong Joo Kim; Jin Suck Suh; Yong Min Huh; Seungjoo Haam

doi:10.1002/mabi.201200448

A biodegradable polymersome containing Bcl-xL siRNA and doxorubicin as a dual delivery vehicle for a synergistic anticancer effect

Hyun Ouk Kim, Eunjung Kim, Yonghee An, Jihye Choi, Eunji H.O. Jang, Eun Bi Choi, Aastha Kukreja, Myeong Hoon Kim, Byunghoon Kang, Dong Joo Kim, Jin Suck Suh, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Combined cancer treatment via co-delivery of siRNAs and an anticancer drug can be a promising strategy due to the synergistic effect of simultaneously minimizing gene/drug administration. In this study, Bcl-xL siRNA and doxorubicin (DOX) are encapsulated into designed methoxy-poly(ethylene glycol)-block-poly(D,L-lactic acid) (mPEG-b-PLA) block copolymer polymersomes (PSomes). A study of the cytotoxicity of Bcl-xL siRNA and DOX co-encapsulated PSomes (CPSomes) shows more inhibited proliferation of MKN-45 and MKN-28 human gastric cancer cell lines than only gene- and drug-loaded ones. Consequently, these results demonstrate that co-delivery of genes and drugs using PSomes results in a synergistic efficacy and indicates the potential of PSomes as efficient nanocarriers for combined cancer therapy.

Original language	English
Pages (from-to)	745-754
Number of pages	10
Journal	Macromolecular Bioscience
Volume	13
Issue number	6
DOIs	https://doi.org/10.1002/mabi.201200448
Publication status	Published - 2013 Jun

All Science Journal Classification (ASJC) codes

Biotechnology
Bioengineering
Biomaterials
Polymers and Plastics
Materials Chemistry

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10.1002/mabi.201200448

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Kim, H. O., Kim, E., An, Y., Choi, J., Jang, E. H. O., Choi, E. B., Kukreja, A., Kim, M. H., Kang, B., Kim, D. J., Suh, J. S., Huh, Y. M., & Haam, S. (2013). A biodegradable polymersome containing Bcl-xL siRNA and doxorubicin as a dual delivery vehicle for a synergistic anticancer effect. Macromolecular Bioscience, 13(6), 745-754. https://doi.org/10.1002/mabi.201200448

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abstract = "Combined cancer treatment via co-delivery of siRNAs and an anticancer drug can be a promising strategy due to the synergistic effect of simultaneously minimizing gene/drug administration. In this study, Bcl-xL siRNA and doxorubicin (DOX) are encapsulated into designed methoxy-poly(ethylene glycol)-block-poly(D,L-lactic acid) (mPEG-b-PLA) block copolymer polymersomes (PSomes). A study of the cytotoxicity of Bcl-xL siRNA and DOX co-encapsulated PSomes (CPSomes) shows more inhibited proliferation of MKN-45 and MKN-28 human gastric cancer cell lines than only gene- and drug-loaded ones. Consequently, these results demonstrate that co-delivery of genes and drugs using PSomes results in a synergistic efficacy and indicates the potential of PSomes as efficient nanocarriers for combined cancer therapy.",

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AU - Jang, Eunji H.O.

AU - Choi, Eun Bi

AU - Kukreja, Aastha

AU - Kim, Myeong Hoon

AU - Kang, Byunghoon

AU - Kim, Dong Joo

AU - Suh, Jin Suck

AU - Huh, Yong Min

AU - Haam, Seungjoo

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AB - Combined cancer treatment via co-delivery of siRNAs and an anticancer drug can be a promising strategy due to the synergistic effect of simultaneously minimizing gene/drug administration. In this study, Bcl-xL siRNA and doxorubicin (DOX) are encapsulated into designed methoxy-poly(ethylene glycol)-block-poly(D,L-lactic acid) (mPEG-b-PLA) block copolymer polymersomes (PSomes). A study of the cytotoxicity of Bcl-xL siRNA and DOX co-encapsulated PSomes (CPSomes) shows more inhibited proliferation of MKN-45 and MKN-28 human gastric cancer cell lines than only gene- and drug-loaded ones. Consequently, these results demonstrate that co-delivery of genes and drugs using PSomes results in a synergistic efficacy and indicates the potential of PSomes as efficient nanocarriers for combined cancer therapy.

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A biodegradable polymersome containing Bcl-xL siRNA and doxorubicin as a dual delivery vehicle for a synergistic anticancer effect

Abstract

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