A benzimidazolium-based organic trication: A selective fluorescent sensor for detecting cysteine in water

Amanpreet Singh; Ajnesh Singh; Narinder Singh; Doo Ok Jang

doi:10.1039/c5ra14501e

A benzimidazolium-based organic trication: A selective fluorescent sensor for detecting cysteine in water

Amanpreet Singh, Ajnesh Singh, Narinder Singh, Doo Ok Jang

Chemistry and Medical Chemistry

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

A benzimidazolium- and imidazolium-based trication was developed as a fluorescence probe for cysteine (Cys). The probe exhibits fluorescence responses to Cys in water with high selectivity and a nano-molar detection limit. Such specificity towards Cys is based on differences in the hydrogen bonding of R1 with Cys, and it provides a method for detecting Cys in the presence of other analytes in a real biological system such as human serum. Density functional theory (DFT) calculations and ¹H NMR titration confirmed the cavity-based recognition of Cys.

Original language	English
Pages (from-to)	72084-72089
Number of pages	6
Journal	RSC Advances
Volume	5
Issue number	88
DOIs	https://doi.org/10.1039/c5ra14501e
Publication status	Published - 2015 Aug 20

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Publisher Copyright:
© The Royal Society of Chemistry 2015.

All Science Journal Classification (ASJC) codes

Chemistry(all)
Chemical Engineering(all)

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abstract = "A benzimidazolium- and imidazolium-based trication was developed as a fluorescence probe for cysteine (Cys). The probe exhibits fluorescence responses to Cys in water with high selectivity and a nano-molar detection limit. Such specificity towards Cys is based on differences in the hydrogen bonding of R1 with Cys, and it provides a method for detecting Cys in the presence of other analytes in a real biological system such as human serum. Density functional theory (DFT) calculations and 1H NMR titration confirmed the cavity-based recognition of Cys.",

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AU - Singh, Narinder

AU - Jang, Doo Ok

PY - 2015/8/20

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AB - A benzimidazolium- and imidazolium-based trication was developed as a fluorescence probe for cysteine (Cys). The probe exhibits fluorescence responses to Cys in water with high selectivity and a nano-molar detection limit. Such specificity towards Cys is based on differences in the hydrogen bonding of R1 with Cys, and it provides a method for detecting Cys in the presence of other analytes in a real biological system such as human serum. Density functional theory (DFT) calculations and 1H NMR titration confirmed the cavity-based recognition of Cys.

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A benzimidazolium-based organic trication: A selective fluorescent sensor for detecting cysteine in water

Abstract

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