A Battery-Powered Opto-Electrophysiology Neural Interface with Artifact-Preventing Optical Pulse Shaping

Adam E. Mendrela; Sung Yun Park; Mihály Vöröslakos; Michael P. Flynn; Euisik Yoon

doi:10.1109/VLSIC.2018.8502353

A Battery-Powered Opto-Electrophysiology Neural Interface with Artifact-Preventing Optical Pulse Shaping

Adam E. Mendrela, Sung Yun Park, Mihály Vöröslakos, Michael P. Flynn, Euisik Yoon

Yonsei Advanced Science Institute

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

7 Citations (Scopus)

Abstract

We present a neural interface IC for high-precision optical stimulation and electrical recording from implanted optoelectrodes with the highest system integration to date. The system combines 12 high-resolution constant-current LED driver channels, 32 recording channels, and an efficient PMU for operation from a low voltage Li battery on a wireless platform. A novel LED driver architecture features a high-efficiency wide-current-range fully-integrated voltage regulator and a high-resolution pulse shaper to minimize recording artifacts from sharp current pulse edges. A prototype, fabricated in 0.18μm CMOS, occupies 7.35mm². The LED driver has a peak efficiency of 50% and consumes 31μW quiescent power. We demonstrate in-vivo that the pulse-shaping scheme prevents stimulation artifacts. Key Words: neural interface, LED driver, optogenetics.

Original language	English
Title of host publication	2018 IEEE Symposium on VLSI Circuits, VLSI Circuits 2018
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	125-126
Number of pages	2
ISBN (Electronic)	9781538667002
DOIs	https://doi.org/10.1109/VLSIC.2018.8502353
Publication status	Published - 2018 Oct 22
Event	32nd IEEE Symposium on VLSI Circuits, VLSI Circuits 2018 - Honolulu, United States Duration: 2018 Jun 18 → 2018 Jun 22

Publication series

Name	IEEE Symposium on VLSI Circuits, Digest of Technical Papers
Volume	2018-June

Other

Other	32nd IEEE Symposium on VLSI Circuits, VLSI Circuits 2018
Country/Territory	United States
City	Honolulu
Period	18/6/18 → 18/6/22

Bibliographical note

Publisher Copyright:
© 2018 IEEE.

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Electrical and Electronic Engineering

Access to Document

10.1109/VLSIC.2018.8502353

Cite this

Mendrela, A. E., Park, S. Y., Vöröslakos, M., Flynn, M. P., & Yoon, E. (2018). A Battery-Powered Opto-Electrophysiology Neural Interface with Artifact-Preventing Optical Pulse Shaping. In 2018 IEEE Symposium on VLSI Circuits, VLSI Circuits 2018 (pp. 125-126). [8502353] (IEEE Symposium on VLSI Circuits, Digest of Technical Papers; Vol. 2018-June). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/VLSIC.2018.8502353

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title = "A Battery-Powered Opto-Electrophysiology Neural Interface with Artifact-Preventing Optical Pulse Shaping",

abstract = "We present a neural interface IC for high-precision optical stimulation and electrical recording from implanted optoelectrodes with the highest system integration to date. The system combines 12 high-resolution constant-current LED driver channels, 32 recording channels, and an efficient PMU for operation from a low voltage Li battery on a wireless platform. A novel LED driver architecture features a high-efficiency wide-current-range fully-integrated voltage regulator and a high-resolution pulse shaper to minimize recording artifacts from sharp current pulse edges. A prototype, fabricated in 0.18μm CMOS, occupies 7.35mm2. The LED driver has a peak efficiency of 50% and consumes 31μW quiescent power. We demonstrate in-vivo that the pulse-shaping scheme prevents stimulation artifacts. Key Words: neural interface, LED driver, optogenetics.",

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Mendrela, AE, Park, SY, Vöröslakos, M, Flynn, MP & Yoon, E 2018, A Battery-Powered Opto-Electrophysiology Neural Interface with Artifact-Preventing Optical Pulse Shaping. in 2018 IEEE Symposium on VLSI Circuits, VLSI Circuits 2018., 8502353, IEEE Symposium on VLSI Circuits, Digest of Technical Papers, vol. 2018-June, Institute of Electrical and Electronics Engineers Inc., pp. 125-126, 32nd IEEE Symposium on VLSI Circuits, VLSI Circuits 2018, Honolulu, United States, 18/6/18. https://doi.org/10.1109/VLSIC.2018.8502353

A Battery-Powered Opto-Electrophysiology Neural Interface with Artifact-Preventing Optical Pulse Shaping. / Mendrela, Adam E.; Park, Sung Yun; Vöröslakos, Mihály et al.
2018 IEEE Symposium on VLSI Circuits, VLSI Circuits 2018. Institute of Electrical and Electronics Engineers Inc., 2018. p. 125-126 8502353 (IEEE Symposium on VLSI Circuits, Digest of Technical Papers; Vol. 2018-June).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Flynn, Michael P.

AU - Yoon, Euisik

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Mendrela AE, Park SY, Vöröslakos M, Flynn MP, Yoon E. A Battery-Powered Opto-Electrophysiology Neural Interface with Artifact-Preventing Optical Pulse Shaping. In 2018 IEEE Symposium on VLSI Circuits, VLSI Circuits 2018. Institute of Electrical and Electronics Engineers Inc. 2018. p. 125-126. 8502353. (IEEE Symposium on VLSI Circuits, Digest of Technical Papers). doi: 10.1109/VLSIC.2018.8502353

A Battery-Powered Opto-Electrophysiology Neural Interface with Artifact-Preventing Optical Pulse Shaping

Abstract

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