5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents

Chung Kyu Ryu; Hye Young Kang; Sang Kook Lee; Kyung Ae Nam; Chang Yong Hong; Won Gil Ko; Byung Hoon Lee

doi:10.1016/S0960-894X(00)00014-7

5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents

Chung Kyu Ryu, Hye Young Kang, Sang Kook Lee, Kyung Ae Nam, Chang Yong Hong, Won Gil Ko, Byung Hoon Lee

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

5-Arylamino-2-methyl-4,7-dioxobenzothiazoles were synthesized as inhibitors of cyclin-dependent kinase 4 (CDK4) and cytotoxic agents. Most of the 4,7-dioxobenzothiazoles exhibited selective inhibitory activities for the CDK4 and cytotoxic potential against human cancer cell lines. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	461-464
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	5
DOIs	https://doi.org/10.1016/S0960-894X(00)00014-7
Publication status	Published - 2000 Mar 6

Bibliographical note

Funding Information:
This research was supported by grants from the Research Institute of Pharmaceutical Science, Ewha Womans University (1997) and the MOST through National R&D Program (97-N6-01-01-A-18) for Women's Universities.

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0960-894X(00)00014-7

Cite this

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title = "5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents",

abstract = "5-Arylamino-2-methyl-4,7-dioxobenzothiazoles were synthesized as inhibitors of cyclin-dependent kinase 4 (CDK4) and cytotoxic agents. Most of the 4,7-dioxobenzothiazoles exhibited selective inhibitory activities for the CDK4 and cytotoxic potential against human cancer cell lines. (C) 2000 Elsevier Science Ltd. All rights reserved.",

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note = "Funding Information: This research was supported by grants from the Research Institute of Pharmaceutical Science, Ewha Womans University (1997) and the MOST through National R&D Program (97-N6-01-01-A-18) for Women's Universities. ",

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T1 - 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents

AU - Ryu, Chung Kyu

AU - Kang, Hye Young

AU - Lee, Sang Kook

AU - Nam, Kyung Ae

AU - Hong, Chang Yong

AU - Ko, Won Gil

AU - Lee, Byung Hoon

N1 - Funding Information: This research was supported by grants from the Research Institute of Pharmaceutical Science, Ewha Womans University (1997) and the MOST through National R&D Program (97-N6-01-01-A-18) for Women's Universities.

PY - 2000/3/6

Y1 - 2000/3/6

N2 - 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles were synthesized as inhibitors of cyclin-dependent kinase 4 (CDK4) and cytotoxic agents. Most of the 4,7-dioxobenzothiazoles exhibited selective inhibitory activities for the CDK4 and cytotoxic potential against human cancer cell lines. (C) 2000 Elsevier Science Ltd. All rights reserved.

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5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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