5-Arylamino-2-methyl-4,7-dioxobenzothiazoles were synthesized as inhibitors of cyclin-dependent kinase 4 (CDK4) and cytotoxic agents. Most of the 4,7-dioxobenzothiazoles exhibited selective inhibitory activities for the CDK4 and cytotoxic potential against human cancer cell lines. (C) 2000 Elsevier Science Ltd. All rights reserved.
Bibliographical noteFunding Information:
This research was supported by grants from the Research Institute of Pharmaceutical Science, Ewha Womans University (1997) and the MOST through National R&D Program (97-N6-01-01-A-18) for Women's Universities.
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry