3,3'-diethylthiatricarbocyanine iodide: A highly sensitive chiroptical reporter of DNA helicity and sequence

Jung Kyu Choi, Alessandro D'Urso, Mitch Trauernicht, Murtaza Shabbir-Hussain, Andrea E. Holmes, Milan Balaz

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Using UV-vis absorption and circular dichroism (CD) spectroscopies, we explored the binding interactions of 3,3'-diethylthiatricarbocyanine iodide (Cy7) with polynucleotides of different sequences and helicity. CD showed to be a very diagnostic tool giving different spectroscopic chiroptical signatures for all explored DNA sequences upon Cy7 binding. Cy7 was able to spectroscopically discriminate between the right handed B-DNA of poly(dG-dC)2 and its left handed Z-DNA counterpart induced by spermine or Co(III)hexamine via nearly opposite induced circular dichroic signal.

Original languageEnglish
Pages (from-to)8052-8062
Number of pages11
JournalInternational journal of molecular sciences
Issue number11
Publication statusPublished - 2011 Nov

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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