2-Phenylbenzofuran derivatives alleviate mitochondrial damage via the inhibition of β-amyloid aggregation

Yun Suk Lee, Hye Yun Kim, Hea Mee Youn, Jae Hong Seo, Youngsoo Kim, Kye Jung Shin

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


To obtain modulators for reducing mitochondrial damage by the inhibition of Aβ oligomer formation, 2-phenylbenzofuran derivatives were designed and prepared. Their inhibitory activity against Aβ fibril formation was screened using ThT fluorescence assay, and the effect of derivatives on mitochondrial function was evaluated using JC-1 and MTT assay. 2-Phenylbenzofuran derivatives with dimethylamino group at p-position had an excellent inhibitory activity against Aβ fibril formation. Particularly, compound 19m alleviated mitochondrial damage remarkably and possessed protective effects against Aβ-induced cytotoxicity.

Original languageEnglish
Pages (from-to)5882-5886
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Issue number21
Publication statusPublished - 2013 Nov 1

Bibliographical note

Funding Information:
This work was financially supported by Research Fund 2012 of The Catholic University of Korea and the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea. (HI12C1087).

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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