New analogues of 2-[2-substituted-3-(3,4-dichlorobenzylamino)propylamino]quinolin-4-ones, 26a, 26b, 31a-e, 34, 35, 38 and 40, have been synthesized and evaluated against Staphylococcus aureus methionyl-tRNA synthetase. All of the synthesized compounds were less active than the reference compound 2. The compounds were also screened against various strains of S. aureus and Enterococci for their antibacterial activities. Among the compounds, 26b, 31c and 31e displayed significant inhibitory properties against various strains of Enterococci compared to compound 2.
Bibliographical noteFunding Information:
This work was supported by a Grant (03-PJ2-PG4-BD02-0001) from the Ministry of Health and Welfare, Republic of Korea and by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korean Government (MOST) (R17-2007-020-01000-0).
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry