2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors

Farhanullah; Taehee Kang; Eun Jung Yoon; Eun Chil Choi; Sunghoon Kim; Jeewoo Lee

doi:10.1016/j.ejmech.2008.02.021

2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors

Farhanullah, Taehee Kang, Eun Jung Yoon, Eun Chil Choi, Sunghoon Kim, Jeewoo Lee

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

New analogues of 2-[2-substituted-3-(3,4-dichlorobenzylamino)propylamino]quinolin-4-ones, 26a, 26b, 31a-e, 34, 35, 38 and 40, have been synthesized and evaluated against Staphylococcus aureus methionyl-tRNA synthetase. All of the synthesized compounds were less active than the reference compound 2. The compounds were also screened against various strains of S. aureus and Enterococci for their antibacterial activities. Among the compounds, 26b, 31c and 31e displayed significant inhibitory properties against various strains of Enterococci compared to compound 2.

Original language	English
Pages (from-to)	239-250
Number of pages	12
Journal	European Journal of Medicinal Chemistry
Volume	44
Issue number	1
DOIs	https://doi.org/10.1016/j.ejmech.2008.02.021
Publication status	Published - 2009 Jan

Bibliographical note

Funding Information:
This work was supported by a Grant (03-PJ2-PG4-BD02-0001) from the Ministry of Health and Welfare, Republic of Korea and by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korean Government (MOST) (R17-2007-020-01000-0).

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery
Organic Chemistry

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10.1016/j.ejmech.2008.02.021

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title = "2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors",

abstract = "New analogues of 2-[2-substituted-3-(3,4-dichlorobenzylamino)propylamino]quinolin-4-ones, 26a, 26b, 31a-e, 34, 35, 38 and 40, have been synthesized and evaluated against Staphylococcus aureus methionyl-tRNA synthetase. All of the synthesized compounds were less active than the reference compound 2. The compounds were also screened against various strains of S. aureus and Enterococci for their antibacterial activities. Among the compounds, 26b, 31c and 31e displayed significant inhibitory properties against various strains of Enterococci compared to compound 2.",

author = "Farhanullah and Taehee Kang and Yoon, {Eun Jung} and Choi, {Eun Chil} and Sunghoon Kim and Jeewoo Lee",

note = "Funding Information: This work was supported by a Grant (03-PJ2-PG4-BD02-0001) from the Ministry of Health and Welfare, Republic of Korea and by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korean Government (MOST) (R17-2007-020-01000-0).",

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doi = "10.1016/j.ejmech.2008.02.021",

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AU - Farhanullah,

AU - Kang, Taehee

AU - Yoon, Eun Jung

AU - Choi, Eun Chil

AU - Kim, Sunghoon

AU - Lee, Jeewoo

N1 - Funding Information: This work was supported by a Grant (03-PJ2-PG4-BD02-0001) from the Ministry of Health and Welfare, Republic of Korea and by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korean Government (MOST) (R17-2007-020-01000-0).

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N2 - New analogues of 2-[2-substituted-3-(3,4-dichlorobenzylamino)propylamino]quinolin-4-ones, 26a, 26b, 31a-e, 34, 35, 38 and 40, have been synthesized and evaluated against Staphylococcus aureus methionyl-tRNA synthetase. All of the synthesized compounds were less active than the reference compound 2. The compounds were also screened against various strains of S. aureus and Enterococci for their antibacterial activities. Among the compounds, 26b, 31c and 31e displayed significant inhibitory properties against various strains of Enterococci compared to compound 2.

AB - New analogues of 2-[2-substituted-3-(3,4-dichlorobenzylamino)propylamino]quinolin-4-ones, 26a, 26b, 31a-e, 34, 35, 38 and 40, have been synthesized and evaluated against Staphylococcus aureus methionyl-tRNA synthetase. All of the synthesized compounds were less active than the reference compound 2. The compounds were also screened against various strains of S. aureus and Enterococci for their antibacterial activities. Among the compounds, 26b, 31c and 31e displayed significant inhibitory properties against various strains of Enterococci compared to compound 2.

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2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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