약물이 탑재된 미소기포와 결합된 sonoporation: 유방암세포에 대한 치료효과

Translated title of the contribution: Sonoporation with echogenic liposome: therapeutic effect on a breast cancer cell

Juhyun Park, Hana Lee, Yougyeong Lee, Jongbum Seo

Research output: Contribution to journalArticlepeer-review

Abstract

Echogenic liposome contains both liquid and gas inside the shell. In ultrasound mediated drug delivery, sonoporation, these new microbubbles can be an attractive drug carrier since they can be loaded water soluble drugs and drug molecules can be unloaded at the specific location with ultrasound sonication. In this paper, the structure of the echogenic liposome was confirmed with EF-TEM and the positive effect of sonoporation with echogenic liposome was comparatively evaluated on MDA-MB-231 cells which is a type of breast cancer cell with Doxorubicin. Control group (Group 1), Doxorubicin only (Group 2), sonoporation with Doxorubicin and hollow microbubbles (Group 3), sonoporation with Doxorubicin loaded echogenic liposome (Group 4) were classified and experiments were conducted. According to the results, Group 4 is at least 1.4 times better in inducing necrosis of cancer cells. Therefore, we conclude echogenic liposome could be one of the most useful form of microbubbles in sonoporation.

Translated title of the contributionSonoporation with echogenic liposome: therapeutic effect on a breast cancer cell
Original languageKorean
Pages (from-to)501-506
Number of pages6
JournalJournal of the Acoustical Society of Korea
Volume41
Issue number5
DOIs
Publication statusPublished - 2022

Bibliographical note

Publisher Copyright:
Copyright © 2022 The Acoustical Society of Korea.

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Instrumentation
  • Acoustics and Ultrasonics
  • Applied Mathematics
  • Speech and Hearing

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