ω-Transaminase-catalyzed asymmetric synthesis of unnatural amino acids using isopropylamine as an amino donor

Eul Soo Park; Joo Young Dong; Jong Shik Shin

doi:10.1039/c3ob40495a

ω-Transaminase-catalyzed asymmetric synthesis of unnatural amino acids using isopropylamine as an amino donor

Eul Soo Park, Joo Young Dong, Jong Shik Shin

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

Isopropylamine is an ideal amino donor for reductive amination of carbonyl compounds by ω-transaminase (ω-TA) owing to its cheapness and high volatility of a ketone product. Here we developed asymmetric synthesis of unnatural amino acids via ω-TA-catalyzed amino group transfer between α-keto acids and isopropylamine.

Original language	English
Pages (from-to)	6929-6933
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	11
Issue number	40
DOIs	https://doi.org/10.1039/c3ob40495a
Publication status	Published - 2013 Oct 28

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1039/c3ob40495a

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abstract = "Isopropylamine is an ideal amino donor for reductive amination of carbonyl compounds by ω-transaminase (ω-TA) owing to its cheapness and high volatility of a ketone product. Here we developed asymmetric synthesis of unnatural amino acids via ω-TA-catalyzed amino group transfer between α-keto acids and isopropylamine.",

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AU - Park, Eul Soo

AU - Dong, Joo Young

AU - Shin, Jong Shik

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Y1 - 2013/10/28

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AB - Isopropylamine is an ideal amino donor for reductive amination of carbonyl compounds by ω-transaminase (ω-TA) owing to its cheapness and high volatility of a ketone product. Here we developed asymmetric synthesis of unnatural amino acids via ω-TA-catalyzed amino group transfer between α-keto acids and isopropylamine.

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AN - SCOPUS:84884689989

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JO - Organic and Biomolecular Chemistry

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ER -

ω-Transaminase-catalyzed asymmetric synthesis of unnatural amino acids using isopropylamine as an amino donor

Abstract

All Science Journal Classification (ASJC) codes

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