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20132022

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  • Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity

    Kaplan, A. L., Confair, D. N., Kim, K., Barros-Álvarez, X., Rodriguiz, R. M., Yang, Y., Kweon, O. S., Che, T., McCorvy, J. D., Kamber, D. N., Phelan, J. P., Martins, L. C., Pogorelov, V. M., DiBerto, J. F., Slocum, S. T., Huang, X. P., Kumar, J. M., Robertson, M. J., Panova, O., Seven, A. B., & 7 othersWetsel, A. Q., Wetsel, W. C., Irwin, J. J., Skiniotis, G., Shoichet, B. K., Roth, B. L. & Ellman, J. A., 2022 Oct 20, In: Nature. 610, 7932, p. 582-591 10 p.

    Research output: Contribution to journalArticlepeer-review

    45 Citations (Scopus)
  • Inactive and active state structures template selective tools for the human 5-HT5A receptor

    Zhang, S., Chen, H., Zhang, C., Yang, Y., Popov, P., Liu, J., Krumm, B. E., Cao, C., Kim, K., Xiong, Y., Katritch, V., Shoichet, B. K., Jin, J., Fay, J. F. & Roth, B. L., 2022 Jul, In: Nature Structural and Molecular Biology. 29, 7, p. 677-687 11 p.

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)
  • Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD

    Cao, C., Barros-Álvarez, X., Zhang, S., Kim, K., Dämgen, M. A., Panova, O., Suomivuori, C. M., Fay, J. F., Zhong, X., Krumm, B. E., Gumpper, R. H., Seven, A. B., Robertson, M. J., Krogan, N. J., Hüttenhain, R., Nichols, D. E., Dror, R. O., Skiniotis, G. & Roth, B. L., 2022 Oct 5, In: Neuron. 110, 19, p. 3154-3167.e7

    Research output: Contribution to journalArticlepeer-review

    Open Access
    29 Citations (Scopus)
  • Structure, function and pharmacology of human itch GPCRs

    Cao, C., Kang, H. J., Singh, I., Chen, H., Zhang, C., Ye, W., Hayes, B. W., Liu, J., Gumpper, R. H., Bender, B. J., Slocum, S. T., Krumm, B. E., Lansu, K., McCorvy, J. D., Kroeze, W. K., English, J. G., DiBerto, J. F., Olsen, R. H. J., Huang, X. P., Zhang, S., & 9 othersLiu, Y., Kim, K., Karpiak, J., Jan, L. Y., Abraham, S. N., Jin, J., Shoichet, B. K., Fay, J. F. & Roth, B. L., 2021 Dec 2, In: Nature. 600, 7887, p. 170-175 6 p.

    Research output: Contribution to journalArticlepeer-review

    71 Citations (Scopus)
  • Nanobody-enabled monitoring of kappa opioid receptor states

    Che, T., English, J., Krumm, B. E., Kim, K., Pardon, E., Olsen, R. H. J., Wang, S., Zhang, S., Diberto, J. F., Sciaky, N., Carroll, F. I., Steyaert, J., Wacker, D. & Roth, B. L., 2020 Dec 1, In: Nature communications. 11, 1, 1145.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    76 Citations (Scopus)